Our understanding of the elusive subluxation and the effects of spinal manipulation has gradually evolved as the science of articular neurology, biomechanics, and motor programming has matured. New insights are consistently accumulating with the proliferation of research investigating the mysteries of kinematics and neuromotor control. In 2011, two papers made important and original contributions to enhance our understanding of the impact of the high-velocity, low-amplitude thrust of manipulation on multifidus muscle function, and the correlation between this and improved clinical outcomes. Let’s review the latest research and discuss implementation of these findings to improve patient outcomes through appropriate integration of manipulation and appropriate exercise training.